Vinylogous acids
Medchemexpress LLC Ensitrelvir fumarate | 2757470-18-9 | 99.99% | C26H21ClF3N9O6 | 100 MG
Ensitrelvir fumarate (S-217622) is the first orally active non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor with an IC50 of 13 nM. It demonstrates EC50 values of approximately 0.4 μM against wild-type SARS-CoV-2 and its Alpha, Beta, Gamma, and Delta variants in cytopathic effect (cpe)-inhibition assays. This compound also dose-dependently inhibits the intrapulmonary replication of SARS-CoV-2 in mice and shows activity against SARS-CoV and MERS-CoV.
- Orally active non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor.
- Inhibits wild-type SARS-CoV-2 and Alpha, Beta, Gamma, and Delta variants.
- Inhibits intrapulmonary replication of SARS-CoV-2 in mice.
- Exhibits activity against SARS-CoV and MERS-CoV.
eMolecules 104997-24-2 | (3-Phenoxy-phenyl)-hydrazine | J & W PharmLab LLC | MFCD08437623 | 200.241 | C12H12N2O | 96.000 | NNc1cccc(Oc2ccccc2)c1 | 5g | 289350549
(3-Phenoxy-phenyl)-hydrazine | J & W PharmLab LLC | 104997-24-2 | MFCD08437623 | 200.241 | C12H12N2O | 96.000 | NNc1cccc(Oc2ccccc2)c1 | 5g | 289350549
eMolecules 1352305-22-6 | 2-(4-Methoxy-phenoxy)-propylamine hydrochloride | Combi-Blocks | MFCD03002050 | 217.690 | C10H16ClNO2 | 96.000 | Cl.COc1ccc(OC(C)CN)cc1 | 1g | 267205878
2-(4-Methoxy-phenoxy)-propylamine hydrochloride | Combi-Blocks | 1352305-22-6 | MFCD03002050 | 217.690 | C10H16ClNO2 | 96.000 | Cl.COc1ccc(OC(C)CN)cc1 | 1g | 267205878
Medchemexpress LLC GS143 | 916232-21-8 | 99.1% | 466.46 | 10 MG
GS143 | 916232-21-8 | 99.1% | 466.46 | 10 MG
Medchemexpress LLC F 13714 fumarate | 208109-39-1 | 99.1% | 10 MG
F 13714 fumarate is a selective 5-HT1A receptor biased agonist that exhibits antidepressant-like properties after a single administration in the mouse model of chronic mild stress.
- Selective 5-HT1A receptor biased agonist.
- Shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress.
- Targets 5-HT1A autoreceptors.
- Normalizes depressive-like behavior in the forced swim test (FST) in UCMS mice.
- Rescues cortical and hippocampal deficits in p-ERK1/2 levels.
- Decreases immobility in mice.
- Decreases rectal body temperature in mice.
- Possesses antidepressant- and anxiolytic-like properties in naive rats.
Medchemexpress LLC IACS-8803 disodium | 2243079-36-7 | 98.8% | 50 MG
IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy. It is intended for research use only.
- Highly potent cyclic dinucleotide STING agonist
- Robust systemic antitumor efficacy
- Shows superior antitumor activity in mice bearing bilateral B16-OVA melanomas
- Targets STING pathway
- Involves immunology/inflammation pathway
Medchemexpress LLC Dup-721 | 104421-21-8 | 98.0% | 276.29 | 50 MG
DuP-721 is a broad-spectrum, orally active antibacterial agent effective against various clinically susceptible and resistant bacteria, especially *M. tuberculosis*. It inhibits *Mycobacterium tuberculosis* strains (1.5-4 μg/ml) and shows no cross-resistance to conventional antituberculosis drugs. In *in vivo* studies, DuP-721 demonstrates protective effects against *M. tuberculosis* infection in mice.
- Effective against susceptible and resistant bacteria
- Targets *M. tuberculosis*
- Inhibits *Mycobacterium tuberculosis* (1.5-4 μg/ml)
- No cross-resistance to antituberculosis drugs
- Protects against *M. tuberculosis* infection in mice
- Inactive against *M. avium* and *M. intracellulare* (>250 μg/ml)
- Inhibits *M. gordonoe* and *M. fortuitum* (3.9 μg/ml)
- Inhibits *M. kansassi* (1.95 μg/ml)
- Inhibits *M. scrofulaceum* (15.6 μg/ml)
Sigma Aldrich Fine Chemicals Biosciences Ethyl indole-3-carboxylate European Pharmacopoeia (EP) Reference Standard | 776-41-0 | MFCD00228454 |
Ethyl indole-3-carboxylate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 189.21 | 776-41-0 | MFCD00228454 |
Medchemexpress LLC HY-18407 100mg Medchemexpress, N-Methylisatoic anhydride CAS:10328-92-4 Purity:>98%
Medchemexpress, HY-P7198 10ug I-309/CCL1 (CHO-expressed), Human CAS: Recombinant Human I-309/CCL1 (CHO-expressed) attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Accela Chembio Inc Ethyl 5-amino-1-methylpyrazole-4-carboxylate | 25g | 31037-02-2 | MFCD00051652 | 98% | Shelf Life: 1260 Days | Moisture Sensitive/light Sensitive
Ethyl 5-amino-1-methylpyrazole-4-carboxylate | 25g | 31037-02-2 | MFCD00051652 | 98% | Shelf Life: 1260 Days | Moisture Sensitive/light Sensitive
Pfaltz & Bauer N-Methylisatoic Anhydride 95% 25G | 10328-92-4
N-Methylisatoic Anhydride 95% 25G | 10328-92-4
eMolecules 90322-37-5 | 2-Oxoindoline-4-carboxylic acid | MFCD10000702 | 1g
Ambeed | 2-Oxoindoline-4-carboxylic acid | 1g | 552648923 | A210504 | 90322-37-5 | MFCD10000702 | 177.159 | C9H7NO3
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Sigma Aldrich Fine Chemicals Biosciences Hypoxanthine >=99.0% | 68-94-0 | MFCD00005725 | 5G
Hypoxanthine >=99.0% | Purity: >=99.0% | Mol Wt: 136.11 | 68-94-0 | MFCD00005725 | 5G
Medchemexpress LLC Tesmilifene fumarate | 1185241-83-1 | MFCD09878272 | 99.9% | 399.48 g/mol | C23H29NO5 | 25 MG
Tesmilifene fumarate (DPPE fumarate) is an H1C receptor antagonist used as a research reagent to potentiate a broad range of cytotoxic agents and may offer some protection to normal cells. It is supplied as a white to off-white solid and as a DMSO solution for laboratory use.
- Potentiates a wide range of cytotoxic agents.
- May provide partial protection to normal cells during cytotoxic exposure.
- High reported purity (99.85%).
- Molecular weight 399.48 g/mol; formula C23H29NO5.
- Available as solid packs and as a 10 mM solution in DMSO.
- Recommended storage: powder at -20 °C or 4 °C; in solvent at -80 °C or -20 °C.
eMolecules 15646-46-5 | Ambeed | 4-(ethoxymethylene)-2-phenyloxazol-5(4H)-one | 1g | 572842109 | A818543 | 217.224 | C12H11NO3
Medchem Express | LOM612 | 5mg | 434310560 | HY-101035 | 2173232-79-4 | 258.300 | C13H10N2O2S
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